descrizione del lavoro

Auxologico is looking for a Postdoc in the Laboratory of Cardiovascular Genetics that will direct and supervise the genetic activities of the lab.
The candidate will work on an international project funded by the Novo Nordisk Foundation in collaboration with the group of Prof. Micheal Toft Overgaard at the University of Aalborg, aiming to decipher the functional effects of rare genetic variants in calmodulin with patient-specific models based on human induced pluripotent stem cells.
The candidate will work in a multidisciplinary team with expertise in clinical cardiology, human genetics, electrophysiology, and stem cell biology.
In particular the candidate will:
Investigate the functional consequences of calmodulin mutations with patient-specific human models integrating molecular, functional (electrophysiology), pharmacological, and live imaging data;
Build multicellular patient-specific models and organoids of human calmodulinopathies;
Contribute to the writing of research papers;
Assist in the supervision of PhD students and contribute to the lab requirements;
Present scientific works at national and international meetings.
Minimum Requirements:
Marked interest in the field of cardiac arrhythmias and/or genetics;
PhD in biology, biotechnology, molecular medicine, genetics, or similar fields;
A solid publication track record;
Ability to work independently;
Good knowledge of written and spoken English;
Preferential Requirements:
Experience in live imaging;
Expertise in molecular biology and/or molecular assays (qPCR, sorting, immunostainings);
Expertise in patch clamp electrophysiology and/or MEAs.
Proficiency in cell cultures, knowledge of human pluripotent stem cell cultures, and differentiation will be an advantage.
Duration of Contract:
This appointment will be initially for 1 year, with extensions for up to 4 years renewed according to progress. Salary will be based on experience.

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